Many of us have experienced the agony of transitioning to a new school with few to no friends in a new setting and having to go through the tedious process of getting to know people again. Bocchi Hitori is all too familiar with this struggle, having recently graduated from elementary school and being forced into middle school. Unfortunately, she has severe social anxiety: she faints when overwhelmed, vomits when worried, and devises impossibly complicated methods to avoid social interaction. It also doesn't help that her lone elementary school buddy, Kai Yawara, will not be attending the same middle school as Bocchi. However, in order to assist her, Kai severes ties with Bocchi and vows to reunite with her after she has befriended all of her classmates in her class.